Associate Scientist Antibody Discovery
Core
Designing and executing antibody discovery workflows using display methods (phage, yeast, mammalian) and NGS to mine antibody pools for sequence discovery, followed by developing high-throughput mammalian cell-based production platforms for recombinant antibodies.
Role type
Associate Scientist, Antibody Discovery & Biologics Production
Builds
High-diversity antibody libraries, lead candidate panels, and recombinant antibody production workflows
Domain
Biotechnology / Immunology / Antibody Engineering
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
antibody discovery, protein engineering, expression and validation of biologics, display methods (phage, yeast, mammalian), library generation, NGS methods, mammalian cell culture (CHO, HEK293), plasmid preparation, AKTA chromatography, HPLC-SEC analysis, molecular assessment (ELISA, CE-SDS, SEC-MALS, DSF)
Preferred skills
ML-based approaches to sequence discovery, leading research experiments, lab and scientific project coordination, training laboratory personnel
Technologies
AKTA chromatography systems, HPLC-SEC, ELISA, CE-SDS, SEC-MALS, DSF, NGS platforms, CHO cells, HEK293 cells
Responsibilities
Design discovery workflows and deliver panels of lead candidates; Apply in-vitro display methods for sequence discovery; Apply NGS methods to mine antibody pools; Develop and optimize high-throughput mammalian cell-based production platforms; Perform DNA preparations for mammalian cell transfection; Establish scalable transient and stable expression workflows; Purify proteins using AKTA chromatography; Analyze purified proteins using HPLC-SEC; Perform molecular assessment of early-stage candidates; Maintain accurate ELN data
Seniority
Mid-level IC, hands-on research
