Scientist, De Novo Discovery
Core
Develop and apply mRNA display and phage display technologies to discover novel binders against challenging protein targets for a clinical-stage biopharmaceutical company.
Role type
Scientist, De Novo Discovery (Hit Discovery)
Builds
mRNA display libraries and screening campaigns for Helicon-based therapeutic programs
Domain
Biopharmaceuticals / Chemical Biology / Protein Engineering
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
mRNA display, phage display, noncanonical amino acid incorporation, reprogrammed translation systems, genetic-code expansion, PCR, cloning, in vitro transcription/translation, next-generation sequencing data analysis
Preferred skills
cell-free protein synthesis, orthogonal translation systems, sequence-activity relationship analysis
Technologies
mRNA display, phage display, next-generation sequencing
Responsibilities
Design and construct diverse mRNA display libraries; incorporate noncanonical amino acids via reprogrammed translation systems; execute high-throughput screening campaigns; analyze sequencing data to identify enriched peptide motifs; implement new technologies and workflow improvements.
Seniority
Early-career Scientist (0-3 years postdoc/industry experience)
