Computational and Experimental Scientist
Core
Close the design-make-test loop for protein design by improving computational models, operating liquid-handling robots, and running end-to-end biophysical assays (BLI/SPR) to translate sequences into kinetics data.
Role type
Senior IC computational and experimental scientist (protein design)
Builds
Production ML models for protein/peptide design, automated liquid-handling workflows, and biophysical assay protocols
Domain
Biotech / Protein Design / Machine Learning / Biophysics
Deliverable
production ML models
Required skills
Protein design, discrete diffusion models, protein language models, BLI/SPR workflows, liquid-handling automation, Python scripting, receptor biology, protein structure analysis, model architecture refinement
Preferred skills
Experience with ESM, ProtT5, RFdiffusion, BindCraft, inference platform optimization, customer-facing technical work
Technologies
ESM, ProtT5, RFdiffusion, BindCraft, Hamilton, Tecan, Opentrons, BLI, SPR
Responsibilities
Improve discrete diffusion and companion folding models for peptide and protein design; Operate and refine an inference platform; Write, debug, and maintain production protocols for liquid-handling robots; Run BLI and SPR workflows end to end; Connect receptor biology, protein structure, scoring, and experimental results to identify failure modes; Support scientific platform users and customer workflows
Seniority
Senior, hands-on IC
