Senior Chemist
Core
Lead chemistry development for enzymatic nucleic acid synthesis workflows, optimizing reactions and analytical methods for oligonucleotide therapeutics.
Role type
Senior IC chemist (oligonucleotide chemistry)
Builds
Enzymatic nucleic acid synthesis workflows and analytical protocols
Domain
Biotechnology / Oligonucleotide chemistry
Required skills
Oligonucleotide synthesis, Modified nucleotide chemistry, Phosphoramidite chemistry, Analytical characterization (HPLC, LC-MS, CE), Reaction optimization, Experimental design, SOP development
Preferred skills
Enzymatic synthesis, Microfluidics integration, DOE/Statistical analysis, Synthetic organic chemistry, ELN systems
Technologies
HPLC, LC-MS, MALDI-MS, PAGE, CE, UV/Vis, Benchling, JMP
Responsibilities
Design and optimize oligonucleotide chemistry workflows; Develop and troubleshoot enzymatic nucleic acid synthesis reactions; Support assay development for enzyme screening; Conduct analytical characterization of products and reaction mixtures; Collaborate with protein engineering and data teams to define performance requirements; Develop robust experimental protocols and technical reports
Seniority
Senior, hands-on IC