ViiV Healthcare (GSK) Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling
Core
Lead model-informed drug discovery across ViiV's Drug Discovery organization by developing and applying mechanistic and translational models to guide HIV drug discovery programs from lead optimization to Phase I clinical studies.
Role type
Senior Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling
Builds
Scalable computational tools, workflows, and prototypes for PBPK, IVIVE, and PK/PD modeling to accelerate candidate selection and dose prediction.
Domain
Biopharmaceuticals, HIV therapeutics, Drug Discovery, DMPK
Deliverable
production ML models | product features
Required skills
PBPK modeling, IVIVE, PK/PD modeling, ADME principles, computational programming (R, Python), mechanistic modeling, empirical modeling (NCA, compartmental), data integration (in vitro, in vivo, omics), regulatory submission support
Preferred skills
Experience with diverse modalities (biologics, ADCs, LNPs, PROTACs), infectious disease/immunology therapeutic areas, matrix leadership
Technologies
Simcyp, GastroPlus, Phoenix WinNonLin, R, Python
Responsibilities
Develop and apply fit-for-purpose mechanistic and translational models to guide drug discovery teams; Translate complex ADME, PK, PD, and translational data into actionable insights; Build scalable computational tools and workflows; Establish best practices and governance for modeling methodologies; Contribute to scientific publications and regulatory submissions.
Seniority
Senior, hands-on IC with leadership responsibilities