PK/PD and QSP modeler, Neuroscience – Principal Scientist / Associate Scientist, DMPK & Modeling
Core
Build quantitative mathematical models (PK/PD, QSP, mechanistic, systems) to drive decision-making in drug discovery and development for neurological diseases.
Role type
Principal/Associate Scientist, PK/PD and QSP Modeler
Builds
Translational PK/PD/efficacy models, mechanistic models, and systems models for novel therapeutic agents
Domain
Neuroscience, Drug Discovery and Development, Quantitative Systems Pharmacology
Deliverable
production ML models
Required skills
Mathematical modeling, PK/PD modeling, QSP modeling, MATLAB, SimBiology, NONMEM, Monolix, Phoenix, Python, R, Biological systems modeling, Neurological disease modeling
Preferred skills
Experience applying modeling to neurological diseases
Technologies
MATLAB, SimBiology, NONMEM, Monolix, Phoenix, Python, R
Responsibilities
Build quantitative models for novel therapeutic agents to treat neurodegenerative and neuromuscular diseases; Collaborate with cross-functional teams to understand target pathway interactions and disease progression; Design and implement modeling & simulation strategies for drug candidate selection and study design; Predict human pharmacologically active dose, dosing schedule, and safety margin for clinical trials.
Seniority
Principal/Associate Scientist, hands-on IC