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Scientist I/II, Organic Chemistry

Alewife, Cambridge, MA💼 Full-time💰 $108,000–$108,000🗓 2026-05-14 → 2026-07-31

Core

Develop, execute, and optimize modern chemical transformations to support Discovery Chemistry efforts, focusing on the rapid synthesis of small molecules and structurally diverse chemical matter.

Role type

Scientist I/II, Organic Chemistry (Discovery Chemistry)

Builds

Efficient chemistry workflows for molecular design–make–test–analyze cycles, including reaction development, analog generation, and route execution.

Domain

Biotechnology / Organic Chemistry / Small Molecule Discovery

Deliverable

production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work

Required skills

Synthetic organic chemistry, High-throughput experimentation (HTE), Reaction workup and purification, Analytical characterization (NMR, chromatography), Multi-step synthesis planning, Troubleshooting complex reactions

Preferred skills

Medicinal chemistry experience, Parallel synthesis, Robotics-enabled chemistry workflows, AI-enabled R&D environments

Technologies

NMR, Chromatography, Robotics platforms, AI/Computational tools

Responsibilities

Design and execute HTE workflows for reaction screening and condition optimization; Plan and perform multi-step synthesis, reaction optimization, and compound characterization; Interpret reaction and analytical data to identify bottlenecks and improve efficiency; Partner with Discovery Chemistry scientists to translate molecular design concepts into executable synthetic strategies; Collaborate with automation teams to build workflows connecting reaction execution with streamlined workup and data generation.

Seniority

Mid-level Scientist (I/II), hands-on IC

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