Principal Research Scientist I, In Vivo Antibody Discovery
Core
Leading innovative immunization-based antibody discovery to identify high-quality therapeutic antibody candidates for challenging targets in Immunology, Neuroscience, and Oncology.
Role type
Principal Research Scientist (In Vivo Antibody Discovery)
Builds
Therapeutic antibody candidates and modalities (including VHH and multispecifics) for AbbVie's Biotherapeutics programs.
Domain
Biopharmaceuticals / Antibody Discovery / Immunology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
antibody discovery platforms (single B cell cloning, immune repertoire screening, hybridoma), antigen engineering, immunization strategies, hit identification, screening cascade design, lead triage, VHH discovery (camelids/transgenics), antibody engineering principles, developability assessment, AI/ML-enabled design, laboratory automation
Preferred skills
rabbit antibody discovery workflows, bioinformatics pipelines (NGS data analysis), computational antibody discovery, leading multidisciplinary discovery teams
Technologies
AI-enabled workflows, machine learning, computational biology, laboratory automation
Responsibilities
Lead antibody discovery programs from hit identification to candidate nomination; Design and execute novel antigen engineering and immunization approaches; Provide technical leadership across B cell-based discovery, immune repertoire screens, and hybridoma; Lead identification of antibody and VHH modalities; Evaluate and implement emerging antibody discovery technologies; Direct hybrid discovery campaigns integrating internal capabilities with external partners; Mentor scientists and provide technical guidance; Contribute to scientific reputation through publications, patents, and presentations
Seniority
Principal, strategy & mentorship