Principal Research Scientist I, In Vitro Preclinical Development
Core
Lead design and development of innovative CAR T-cell therapies using mRNA-tLNP technology for oncology and autoimmune diseases.
Role type
Principal Research Scientist I, In Vitro Preclinical
Builds
mRNA-tLNP pipeline programs from early discovery through IND-enabling studies
Domain
Immunology / Oncology / Cell Therapy
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
CAR-T biology, genetic medicine approaches, novel biological systems, assay development, T cell biology, immuno-oncology, flow cytometry, functional assay design, principal investigator leadership, scientific communication, patent invention
Preferred skills
in situ/in vivo delivery platforms for CAR-T therapies
Technologies
mRNA-tLNP, CAR-T therapies
Responsibilities
Develop and implement original research and development strategies for in vivo CAR T-cell therapies, collaborate with Biotherapeutics and Genetic Medicine stakeholders, serve as organizational SME in next-generation cell therapy engineering, oversee CAR-T project execution from inception through preclinical stages, generate new scientific proposals and lead those efforts, represent project teams by communicating scientific strategy and risk assessment, author publications and patents, present at leading scientific conferences, mentor and supervise a team
Seniority
Principal, hands-on IC with mentorship