Scientist I / II, tLNP Process Development
Core
Developing manufacturing processes for targeted lipid nanoparticles (tLNPs) to deliver mRNA therapeutics, focusing on encapsulation, bioconjugation, and purification.
Role type
Scientist I / II, Process Development (Biologics CMC)
Builds
Non-GMP pre-clinical and GMP clinical supply of purified tLNP bulk drug product
Domain
Biopharmaceuticals / mRNA therapeutics / Lipid Nanoparticle manufacturing
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
mRNA encapsulation (non-microfluidic systems), bioconjugation, tangential flow filtration, process scale-up, colloidal science, experimental design, GMP compliance
Preferred skills
lipid chemistry, gram-scale process scaling, statistical modeling
Technologies
impinging jet, coaxial jet, multi-inlet vortex mixer, tangential flow filtration, ultrafiltration/diafiltration
Responsibilities
Design and execute experiments for unit operations (encapsulation, bioconjugation, filtration); scale up processes to commercial batch sizes; author regulatory documents and patents; collaborate with cross-functional teams
Seniority
Scientist I (BS +5 yrs or MS +2 yrs) / Scientist II (BS +7 yrs or MS +5 yrs), hands-on IC