Senior Scientist, Biochemical and Cellular Pharmacology
Core
Lead GPCR pharmacology research to discover and characterize therapeutic drug candidates for cardiovascular, renal, or metabolic diseases.
Role type
Senior Scientist, Biochemical and Cellular Pharmacology
Builds
Molecular pharmacology assays and screening cascades for IND candidate selection
Domain
Biopharma, GPCR pharmacology, cardiovascular/renal/metabolic disease
Deliverable
physical/clinical work
Required skills
GPCR pharmacology, assay development and optimization, signal transduction pathways, allosteric modulation, biased signaling, data analysis, scientific mentorship, strategic leadership
Preferred skills
CRISPR, primary cell culture, protein-protein interactions, secondary messengers, biosensors
Technologies
cAMP, calcium flux, BRET/FRET, Beta-arrestin recruitment, gene-editing techniques
Responsibilities
Design and execute advanced molecular pharmacology assays, provide strategic GPCR expertise on project teams, oversee in vitro pharmacological characterization, mentor junior scientists, analyze data and present findings to leadership
Seniority
Senior, hands-on IC with leadership responsibilities