Senior Scientist (Drug Metabolism & Pharmacokinetics)
Core
Lead DMPK strategy and oversee non-clinical studies to elucidate ADME and PK properties of small molecule drug candidates for discovery and development.
Role type
Senior IC drug metabolism and pharmacokinetics project leader
Builds
Non-clinical DMPK studies and regulatory briefing packages for small molecule drug candidates
Domain
Pharmaceutical R&D, Drug Metabolism & Pharmacokinetics
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
ADME and PK data integration, non-clinical study design and interpretation, regulatory filing support, risk identification and mitigation, cross-functional team leadership
Preferred skills
Multi-modality project experience (peptides, degraders, conjugates), IND-enabling and clinical development support, PK/PD and PBPK modeling
Technologies
Bioanalysis, drug transport, pharmacokinetics modeling platforms
Responsibilities
Serve as DMPK representative on multidisciplinary project teams, lead DMPK strategy and author regulatory briefing sections, design and oversee in vitro and in vivo ADME/PK studies, translate nonclinical data into human PK and dose predictions, identify DMPK-related risks and develop mitigation strategies
Seniority
Senior, hands-on IC with project leadership
