DMPK Scientist
Core
Develop and drive DMPK and PK/PD strategy for drug discovery projects, integrating in silico ADME predictive solutions and physicochemical data to impact multiparameter optimization.
Role type
Principal DMPK Scientist (Drug Discovery)
Builds
Novel chemical entities and druggable molecules for therapeutic development
Domain
Pharmaceutical drug discovery and preclinical development
Deliverable
production ML models
Required skills
ADME principles, in vitro/in vivo drug metabolism, transporter approaches, PK/PD modeling, PBPK modeling, Phoenix/WinNonlin, SimCYP, Monolix, MATLAB SimBiology, regulatory reporting, multiparameter optimization
Preferred skills
PI experience, scientific strategy, data analysis, cross-functional collaboration
Technologies
Phoenix/WinNonlin, SimCYP, Monolix, MATLAB SimBiology
Responsibilities
Develop DMPK and PK/PD strategy, represent DMPK on project teams, collaborate with CROs to generate data, analyze and integrate ADME/DMPK data, author regulatory reports, establish predictive computational ADME/DMPK models
Seniority
Senior, hands-on IC with strategic responsibilities