Principal Scientist - Oligonucleotide Design and Chemistry
Core
Lead the design, synthesis, purification, and characterization of novel oligonucleotide modalities (ASOs, siRNAs, saRNAs) for drug discovery programs.
Role type
Principal Scientist (Group Leader), hands-on IC with mentorship
Builds
Novel oligonucleotide therapeutics for Genentech's nucleic-acid based medicines portfolio
Domain
Biopharma / Oligonucleotide Chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Oligonucleotide chemistry, siRNA therapeutics, ASO therapeutics, chemical synthesis, purification, analytical characterization, backbone modifications, delivery technologies, lab instrumentation management, scientific mentoring, cross-functional collaboration
Preferred skills
Bioconjugation, linker discovery, bioconjugation optimization
Responsibilities
Lead design and synthesis of novel oligonucleotides; mentor junior scientists in synthesis and analytics; partner with biology/biochemistry teams on assay design and data interpretation; communicate scientific progress to stakeholders; manage laboratory instrumentation and operations
Seniority
Principal, technical leader & mentor