Oligo Discovery Process Chemistry Principal Scientist
Core
Lead process discovery for oligonucleotide therapeutics (ASOs, siRNA, SSO, RNA editors) by developing and troubleshooting solid-phase synthesis routes from milligram to gram scale and generating in vivo study material.
Role type
Principal Scientist, Oligonucleotide Process Chemistry
Builds
Rodent and NHP-scale API0 for in vivo studies using ÄKTA Oligosynt synthesizers
Domain
Biopharma / Oligonucleotide Therapeutics
Required skills
Solid-phase oligonucleotide synthesis (SPOS), Chromatography and purification strategies, ÄKTA Oligosynt/Mermade12 synthesizers, LC/HRMS and UPLC analytics, RNA therapeutics biology (ASO, siRNA, SSO, RNA Editors)
Preferred skills
Mentorship and project management, Conjugation chemistries, Translating discovery routes to larger-scale synthesis
Technologies
ÄKTA Oligosynt, Mermade12, Unicorn software, IEX, RP, AEX, LC/HRMS, UPLC, LC/MS
Responsibilities
Develop and optimize chromatography/purification strategies for scale-up, Generate in vivo study material at rodent and NHP scale, Establish synthesis and purification workflows and draft SOPs, Partner with analytical and conjugate chemistry teams, Serve as SME for process chemistry in cross-matrix meetings
Seniority
Principal, hands-on IC with mentorship
