Principal Scientist, Oligonucleotide (PMO, ASO) Development
Core
Lead chemical synthesis strategy for PMO and modified ASO payload molecules, managing execution internally and across CDMOs to support preclinical process, analytical development, and GMP manufacture for IND-enabling studies.
Role type
Principal Scientist, Oligonucleotide Development (Process Chemistry & CMC)
Builds
Preclinical assets and clinical supply for oligonucleotide therapeutics
Domain
Biotechnology / Gene Therapy / Oligonucleotide Chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Oligonucleotide synthesis and purification, Process chemistry development, Analytical development and impurity control, CDMO management and technology transfer, Regulatory CMC documentation (Module 3), GMP compliance
Preferred skills
Advanced degree in relevant field, Clinical-stage biotech R&D experience, Strategic problem solving in shifting priorities
Technologies
PMO, ASO, Bioconjugation platforms
Responsibilities
Design and optimize scalable manufacturing processes for PMO/ASO payloads, Define analytical strategies for impurity control and physicochemical characterization, Lead technology transfer to external CDMOs, Author and review regulatory Module 3 sections for IND/IMPD filings, Review and approve cGMP documentation (MBRs, Campaign Reports), Create technical source documents and presentations
Seniority
Principal, hands-on IC with strategic oversight