Senior Scientist - Nucleic Acids Payload Engineering
Core
Lead efforts to develop non-viral gene delivery platforms, specifically enhancing DNA delivery and nuclear shuttling to mitigate immunogenicity for gene therapy treatments.
Role type
Senior Scientist, Nucleic Acids Payload Engineering
Builds
Non-viral gene delivery platform (Super PiggyBac transposase-based system)
Domain
Biopharma / Gene Therapy / Molecular Biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
high-throughput library screening in mammalian cell systems, nucleic acid manipulation, molecular cloning (IVT, Golden Gate, Gibson assembly), functional molecular assays (Western blot, ddPCR, qRT-PCR), DNA delivery optimization, nuclear shuttling strategies
Preferred skills
Next-Generation Sequencing (NGS), work with primary cells (hepatocytes, T cells, monocytes/macrophages)
Technologies
Super PiggyBac transposase, IVT, Golden Gate cloning, Gibson assembly, ddPCR, qRT-PCR
Responsibilities
Conceptualize and evaluate novel strategies for nuclear shuttling of donor DNA, perform rigorous research projects using hypothesis testing and screening methodologies, collaborate with cross-functional teams to convert research data into clinical and drug discovery frameworks
Seniority
Senior, hands-on IC
