Scientist/Senior Scientist
Core
Developing functional assays and pre-clinical models to measure endothelial cell function decline and test reprogramming medicines for vascular tissue.
Role type
Scientist (Discovery Biology)
Builds
Pre-clinical reprogramming medicines for vascular tissue
Domain
Biotechnology / Epigenetic Aging / Vascular Biology
Deliverable
physical/clinical work
Required skills
primary cell isolation, functional characterization, mouse model work, transgenic manipulation, nucleic acid delivery, in vivo delivery methods, experimental data analysis
Preferred skills
drug development program experience, leading pre-clinical study design, single cell genomics, pooled screening approaches
Technologies
viral vectors, CRISPR fitness screens, Perturb/CROP-seq
Responsibilities
Develop functional assays and pre-clinical models to measure endothelial cell function; Collaborate with Functional Genomics and Predictive Modeling teams; Measure the impact of mRNA reprogramming medicines; Engineer in vivo nucleic acid delivery methods; Analyze and interpret experimental data to drive pre-clinical decision making
Seniority
Mid-Senior (Ph.D. + 5+ years)