Scientist, In Vivo Pharmacology, Neuroscience
Core
Conducts and directs in vivo pharmacology studies in mice to evaluate therapeutic efficacy and pharmacodynamics for neurodegenerative, neuromuscular, and neuropsychiatric diseases.
Role type
Senior In Vivo Pharmacology Scientist (Neuroscience)
Builds
Preclinical data supporting the development of small molecules, biologics, and genetic medicines for serious neurological diseases.
Domain
Neuroscience / Preclinical Pharmacology
Required skills
in vivo mouse studies, pharmacodynamic (PD) analysis, mRNA/protein expression analysis, neuropathology assessment, transcriptomics, physiology assays, CRO management, stereotaxic surgery, bioluminescence imaging, RNA biology, genetic medicine delivery
Preferred skills
neurodegenerative disease modeling, neuromuscular disease modeling, splice modulation, blood-brain barrier delivery, CNS tissue collection, transcriptomics, proteomics, CRO experience
Technologies
IV, SC, IP, PO, ICV dosing, mRNA/protein expression, transcriptomics, proteomics, bioluminescence imaging
Responsibilities
Perform and direct in vivo pharmacology studies in mice including dosing and tissue collection; Analyze PD and efficacy readouts including neuropathology and transcriptomics; Manage in vivo studies conducted at contract research organizations (CROs); Serve as an in vivo pharmacology representative on program and platform teams
Seniority
Senior, hands-on IC