Senior Scientist, In Vivo Pharmacology, Neuroscience
Core
Directs in vivo pharmacology studies in mice to evaluate therapeutic candidates for neurodegenerative, neuromuscular, and neuropsychiatric diseases.
Role type
Senior Scientist, In Vivo Pharmacology
Builds
Therapeutics for patients with serious neurological and neuromuscular diseases
Domain
Neuroscience / Biopharmaceuticals
Required skills
in vivo pharmacology study design and execution, mouse handling and dosing, pharmacodynamic and efficacy readout analysis, assay development, mouse model development, CRO management, program strategy contribution, external asset evaluation
Preferred skills
PhD in Neuroscience, genetic medicines expertise (siRNA/ASO delivery across BBB), neurodegenerative disease modeling, neuromuscular disease modeling, RNA biology and splice modulation, rodent stereotaxic surgery, in vivo bioluminescence imaging, transcriptomics and proteomics, CRO experience
Technologies
IV, SC, IP, PO, ICV dosing, mRNA/protein expression analysis, transcriptomics, proteomics, immunohistochemistry, muscle physiology assays, bioluminescence imaging
Responsibilities
Perform and direct in vivo pharmacology studies in mice, analyze PD and efficacy readouts, develop new assays and mouse models, manage studies at CROs, serve as biology lead on program teams, evaluate external assets
Seniority
Senior, hands-on IC