Senior Scientist, In Vivo Pharmacology, Neuroscience
Core
Directing in vivo pharmacology studies in mice to evaluate therapeutic candidates for neurodegenerative, neuromuscular, and neuropsychiatric diseases.
Role type
Senior Scientist, In Vivo Pharmacology (Neuroscience)
Builds
Therapeutic candidates for neurodegenerative, neuromuscular, and neuropsychiatric diseases
Domain
Neuroscience / In Vivo Pharmacology
Required skills
in vivo mouse studies, pharmacodynamic (PD) and efficacy readouts, assay development, mouse model development, CRO management, program strategy contribution, external asset evaluation
Preferred skills
PhD in Neuroscience, genetic medicines (siRNA/ASO) delivery across BBB, neurodegenerative disease modeling, neuromuscular disease modeling, RNA biology, mouse handling, CNS tissue collection, stereotaxic surgery, bioluminescence imaging, transcriptomics/proteomics, CRO experience
Technologies
IV, SC, IP, PO, ICV dosing, mRNA/protein expression analysis, transcriptomics, proteomics, bioluminescence imaging
Responsibilities
Perform and direct in vivo pharmacology studies in mice including dosing and tissue collection; Analyze PD and efficacy readouts; Develop new assays and mouse models; Manage studies at CROs; Serve as biology lead on program teams; Evaluate external assets
Seniority
Senior, hands-on IC