Scientist, In Vivo Pharmacology, Neuroscience
Core
Directs in vivo pharmacology studies in mice to evaluate therapeutic efficacy and pharmacodynamics for neurodegenerative, neuromuscular, and neuropsychiatric diseases.
Role type
Senior In Vivo Pharmacology Scientist (Neuroscience)
Builds
Preclinical data supporting clinical proof-of-concept for small molecules, biologics, and genetic medicines.
Domain
Neuroscience / Preclinical Pharmacology
Required skills
in vivo mouse study design and execution, pharmacodynamic (PD) and efficacy readout analysis, CRO management, mRNA/protein expression analysis, neuropathology assessment, transcriptomics, muscle physiology assays, rodent stereotaxic surgery, in vivo bioluminescence imaging.
Preferred skills
neurodegenerative disease modeling (Alzheimer's, Parkinson's, Huntington's), neuromuscular disease modeling (ALS, muscular dystrophies), RNA biology and splice modulation, siRNA/ASO delivery across blood-brain barrier, CNS tissue collection.
Responsibilities
Perform and direct in vivo pharmacology studies in mice including dosing and tissue collection; Analyze PD and efficacy readouts including transcriptomics and physiology; Manage in vivo studies conducted at contract research organizations (CROs); Serve as in vivo pharmacology representative on program and platform teams.
Seniority
Senior, hands-on IC