Principal Scientist (all genders) Structural Biology
Core
Provide scientific leadership in interdisciplinary projects to elucidate structural mode of action and enable structure-based design for macromolecular complexes of antibodies, multispecifics, and molecular degraders.
Role type
Principal Scientist (Structural Biology)
Builds
Integrated, end-to-end experimental strategies for structural enablement spanning protein and sample generation, data acquisition, and structural model building.
Domain
Life Science / Structural Biology / Drug Discovery
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
X-ray crystallography (sample generation, data collection, processing, refinement), protein complex structure determination, antibody-antigen complex analysis, protein degrader complex analysis, cryo-EM (single-particle), biophysical characterization (HDX-MS, SAXS, Refeyn, FIDA, DSF), cloud-based/HPC data management, LINUX scripting, AI/ML-based structure prediction, CRO coordination, scientific communication, mentoring
Preferred skills
Oncology/immunology/neuroscience drug discovery experience, introducing new technologies
Technologies
X-ray crystallography software, cryo-EM, HDX-MS, SAXS, Refeyn, FIDA, DSH, LINUX, cloud platforms
Responsibilities
Design, execute, and drive complex structural biology projects; strengthen X-ray crystallography capabilities; complement cryo-EM workflows; coordinate CRO and collaboration partner activities; communicate scientific findings to cross-functional teams; mentor junior scientists
Seniority
Principal, hands-on IC with leadership and mentorship