Process Development Engineer
Core
Develop and scale manufacturing processes for RNA and DNA oligonucleotide synthesis and purification from nanomole to millimole scales.
Role type
Process Development Engineer (Oligonucleotide Manufacturing)
Builds
Oligonucleotide products for genome engineering applications
Domain
Biotechnology / Chemical Engineering / Oligonucleotide Synthesis (via careerplan.io/jobs/0264e8f4-2a33-4a03-8f81-c1921ee83ca4-process-development-engineer-at-synthego)
Required skills
Oligonucleotide synthesis and purification, HPLC operation, automated liquid handling, aseptic techniques, data analysis (Python, SQL), IQ/OQ/PQ execution, SOP development
Preferred skills
Oligonucleotide chemistry (fluorophores/quenchers), qPCR, fluorescence assays, biotechnical instrumentation programming
Technologies
HPLC, oligonucleotide synthesizers, peptide synthesizers, tangential flow filtration, liquid handlers, Python, SQL
Responsibilities
Design and implement methods to scale synthesis and purification; synthesize, purify, and analyze oligonucleotides to specifications; analyze assay data (UV, chromatograms, mass spectrometry) to optimize conditions; conduct experimentation using automated instrumentation; write development protocols and reports; conduct IQ/OQ/PQ for new instrumentation; update Standard Operating Procedures and Batch Records; train staff on new processes.
Seniority
Mid-level (2-5 years experience)