Senior Principal Scientist/Principal Scientist, Immune Engagers
Core
Lead biology strategy and execution for novel immune cell engagers and multispecific immune modulators to advance programs from target validation toward clinical development.
Role type
Senior Principal Scientist (Immune Engagers)
Builds
Novel immune cell engagers and multispecific immune modulators for oncology
Domain
Oncology / Cancer Immunology
Required skills
Cancer biology, Immunology, T cell biology, Myeloid cell biology, Tumor microenvironment biology, Immune-cell functional assays, Multiparameter flow cytometry, Antibody engineering, Multispecific biologic discovery, Hypothesis formulation, Experimental design
Preferred skills
T-cell engager discovery, Myeloid cell-engager discovery, IND-enabling or early clinical activities, Multidisciplinary stakeholder alignment, End-to-end program perspective, Next-generation modality innovation, Mentoring
Technologies
Multiparameter flow cytometry, In vitro assays, Ex vivo assays
Responsibilities
Identify and validate tumor-targeting strategies for immune cell engagers, Lead biology strategy and execution for multidisciplinary drug-discovery programs, Design and interpret mechanistic studies of immune cell activation and anti-tumor activity, Present evidence-based recommendations and development plans at governance reviews, Supervise and develop scientists, Contribute to immune-engager strategy and target prioritization
Seniority
Senior Principal Scientist, hands-on IC with leadership