Senior Scientist I/II, Hematology- Target Biology and Discovery
Core
Identify and validate novel therapeutic targets and advance early drug-discovery programs for hematologic cancers, specifically myeloid malignancies like AML/MDS.
Role type
Senior Scientist I/II, Target Biology and Discovery
Builds
Early drug-discovery programs for hematologic malignancies
Domain
Biotechnology / Oncology / Hematology
Required skills
Molecular and cellular biology, CRISPR-based perturbation, gene knockdown/overexpression, chemical probes, western blotting, qPCR, imaging, cellular phenotyping, mammalian cell culture, multiparameter flow cytometry, assay development, experimental design
Preferred skills
Primary hematopoic or patient-derived samples, CRISPR-based functional genomics, high-throughput screening, pharmaceutical/biotech environment experience, AML/MDS knowledge
Technologies
CRISPR, qPCR, western blotting, flow cytometry
Responsibilities
Identify critical drug-discovery questions and develop experimental strategies; Conduct studies for target identification/validation/mechanism of action; Develop and optimize cellular assays; Establish disease-relevant hematologic models; Collaborate in multidisciplinary environments to prioritize hypotheses; Analyze datasets and communicate results
Seniority
Senior, hands-on IC