Process Development Associate, Synthetic and Bioconjugation Scale-Up Technologies (SBST) (1 of 2)
Core
Develop conjugation and purification processes for bioconjugation of proteins to small-molecules, optimizing them for GMP production and technology transfer to CDMOs.
Role type
Process Development Associate II (IC)
Builds
GMP-ready bioconjugation and purification processes for preclinical manufacturing
Domain
Biopharmaceuticals / Protein Bioconjugation
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
protein purification, technology transfer, bioconjugation processes (lysine/cysteine/site-specific), chromatography, ultrafiltration/diafiltration, membrane technologies, statistical design of experiments (DOE), analytical characterization (electrophoresis, mass spectrometry, HPLC, UV spectroscopy), GMP compliance, lab safety
Preferred skills
antibody bioconjugates experience, downstream purification techniques, process analytical technologies (PAT), predictive process modeling
Technologies
HPLC, mass spectrometry, electrophoresis, UV spectroscopy, chromatography, ultrafiltration/diafiltration
Responsibilities
Design and develop scalable GMP-ready bioconjugation and purification processes; Optimize processes using DOE; Collaborate with analytical groups to establish characterization techniques; Transfer processes to CDMOs or internal manufacturing suites; Author technology transfer and regulatory documentation; Mentor junior team members; Maintain lab equipment and organization
Seniority
Mid-level, hands-on IC