Principal Scientist, Translational Clinical Biomarkers - Hematology/Oncology
Core
Lead strategic design, execution, and interpretation of translational and clinical biomarker strategies for oncology and hematology drug development programs.
Role type
Principal Scientist, Translational Clinical Biomarkers
Builds
Decision-centric biomarker strategies informing program development, patient selection, and go/no-go decisions.
Domain
Oncology / Hematology / Translational Medicine / Drug Development
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Translational biomarker strategy, Cancer biology, Mechanism of action integration, Cross-functional leadership, Complex data synthesis, Precision medicine approaches, Biomarker modality expertise (NGS, ctDNA, MRD), Strategic prioritization
Preferred skills
Multi-stage clinical development experience, Companion diagnostic development, Novel therapeutic modality expertise (ADC, cell therapy), Scientific mentorship
Technologies
NGS, ctDNA, MRD, Immunohistochemistry, Flow cytometry, Gene-expression profiling, Proteomics
Responsibilities
Develop integrated biomarker strategies across oncology and hematology programs; Translate disease biology into translational hypotheses; Define biomarker approaches for key development questions; Lead interpretation of biomarker and clinical datasets; Partner with cross-functional teams including Discovery, Clinical Development, and Regulatory; Provide scientific guidance and mentorship to biomarker scientists.
Seniority
Principal, strategic leadership & mentorship
