Principal Scientist, Translational Clinical Biomarkers - Hematology/Oncology
Core
Lead the design, execution, analysis, and communication of translational and clinical biomarker strategies for oncology and hematology drug development programs.
Role type
Principal Scientist, Translational Clinical Biomarkers
Builds
Decision-centric biomarker strategies informing program development decisions (proof of biology, dose selection, patient selection, go/no-go).
Domain
Oncology / Hematology / Translational Medicine / Drug Development
Required skills
Translational biomarker strategy, Cancer biology, Mechanism of action, Pharmacodynamics, Molecular heterogeneity, Cross-functional leadership, Data synthesis, Strategic prioritization, Scientific communication, Regulatory considerations
Preferred skills
Precision medicine, Companion diagnostics, Immuno-oncology, Novel therapeutic modalities (ADC, cell therapy), Multi-stage clinical development experience, Mentoring
Technologies
NGS, ctDNA, MRD, Immunohistochemistry, Flow cytometry, Gene-expression profiling, Proteomics
Responsibilities
Develop integrated biomarker strategies across oncology/hematology programs; Translate disease biology into translational hypotheses; Define biomarker approaches for key development questions; Partner with cross-functional teams (Discovery, Clinical, Regulatory, etc.); Lead interpretation of complex biomarker datasets; Evaluate emerging biomarker technologies; Provide scientific guidance and mentorship to scientists.
Seniority
Principal, strategic leadership & mentorship