Principal Scientist, Discovery BioSciences Genomics, Oncology TRC
Core
Lead wet lab research in oncology drug discovery using multi-omics (genomics, functional genomics, spatial transcriptomics) to identify targets, validate mechanisms, and support translational studies.
Role type
Principal Scientist, Discovery BioSciences Genomics (Oncology)
Builds
Novel oncology therapeutics and drug discovery programs
Domain
Life Sciences / Oncology / Genomics
Required skills
Single-cell RNA-seq, spatial transcriptomics, NGS workflows, CRISPR screening, gene perturbation methods, molecular cloning, cell culture (2D/3D/organoids), flow cytometry, data analysis (bioinformatics/AI/ML)
Preferred skills
Cancer biology, in vivo studies, FFPE/clinical sample handling, automation, large-scale oncology datasets (DepMap, cBioPortal, TCGA)
Technologies
10x Visium HD, Bruker CosMx, 10x Xenium, GraphPad Prism, FlowJo, Jira, LIMS, Confluence
Responsibilities
Design and execute genomic/functional assays, run NGS workflows, manage research projects, collaborate cross-functionally, train team members, document and present findings
Seniority
Principal, hands-on IC