Principal Scientist, DMPK
Core
Lead drug metabolism and pharmacokinetic (DMPK) efforts for peptide and protein therapeutics in oncology and immunology discovery.
Role type
Principal Scientist (director-level equivalent), hands-on IC
Builds
Drug candidates for oncology and immunology portfolios
Domain
Pharmaceutical R&D, Biologics, Oncology, Immunology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
DMPK strategy design, ADME characterization, in vitro/in vivo study design, PK/PD data interpretation, biologics expertise, cross-functional leadership
Preferred skills
PBPK modeling, IND-enabling experience, structure-activity relationship optimization
Technologies
Phoenix WinNonlin, Berkeley Madonna, MATLAB
Responsibilities
Lead DMPK discovery for peptides/proteins; characterize ADME properties; design and analyze PK/PD studies; contribute to global DMPK strategy; represent PDMB on cross-functional teams
Seniority
Principal, strategy & mentorship
