Senior Scientist, Respiratory Discovery (Biology & Translational Models)
Core
Design and execute complex experimental strategies using human-relevant in vitro, ex vivo, and tissue-engineered models to identify targets, validate mechanisms, and support therapeutic strategies for chronic lung diseases.
Role type
Senior Scientist, Respiratory Discovery (Biology & Translational Models)
Builds
Mechanistic datasets, target validation reports, and translational hypotheses for early discovery programs
Domain
Respiratory biology, chronic lung diseases (COPD, asthma, fibrosis), tissue engineering
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Cell culture techniques, Image analysis, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Organoid culture, Target validation, Translational biology, Pulmonary disease research
Preferred skills
Macrophage/fibroblast/immune-stromal co-culture, Patient-derived respiratory tissues, Transcriptomic datasets (bulk/scRNA-seq), Spatial biology, Organoid biology
Technologies
ALI cultures, Organ-on-chip, Precision-cut lung slices (PCLS), Luminex, Olink, AlphaLISA, Confocal microscopy, High-content imaging
Responsibilities
Design experimental strategies to interrogate epithelial, stromal, vascular, and immune-cell interactions; Develop and apply disease-relevant experimental systems; Generate mechanistic datasets to investigate epithelial dysfunction and tissue remodeling; Utilize imaging, transcriptomic, proteomic, and spatial profiling approaches; Support translational biomarker discovery and validation; Partner with computational biology and translational teams to integrate multi-omics datasets; Support evaluation of biologics and small molecules; Synthesize and interpret complex biological datasets to support target prioritization and portfolio decision-making
Seniority
Senior, hands-on IC
