Associate Principal Scientist, Upstream Process Development
Core
Design, develop, and optimize upstream cell culture processes for biologics to support clinical trials and commercial manufacturing.
Role type
Associate Principal Scientist (Upstream Process Development)
Builds
High-yield, robust, scalable cell culture processes for recombinant protein production
Domain
Biologics / Biopharmaceutical Manufacturing
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Mammalian cell culture, fed-batch processes, CHO cell biology, bioreactor scale-up, statistical design of experiments, regulatory filing, cross-functional collaboration, scientific publication
Preferred skills
Cell culture media development, high-throughput microbioreactor systems, perfusion process development, metabolic flux analysis, omics, machine learning, PAT integration, technology transfer
Technologies
SIMCA, JMP, microbioreactors, bioreactors
Responsibilities
Lead upstream process development for first-in-human and commercial processes; execute process characterization and regulatory filings; partner with cross-functional teams to achieve quality by design; drive process improvement initiatives; collaborate with academia and vendors on new technologies; publish and patent externally.
Seniority
Senior, hands-on IC with mentorship responsibilities
