Senior Scientist Genomic Medicine BioAnalytics Characterization
Core
Develop and implement advanced characterization strategies for gene therapy candidates (viral vectors, nonviral particles) using LC-MS to support CMC product development from pre-candidate selection through commercialization.
Role type
Senior Scientist, BioAnalytics Characterization (Genomic Medicine)
Builds
Structural and functional characterization of gene therapy products for drug development
Domain
Biopharma / Genomic Medicine / Mass Spectrometry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
LC-MS protein characterization, protein identification, protein quantitation, peptide mapping, proteomics software (Spectronaut, Genedata Expressionist, Protein Metrics, Skyline, Proteome Discoverer), HCP clearance profiling, oligonucleotide mapping, automated data workflows, technical documentation for regulatory filings
Preferred skills
Automation implementation, AI-driven analytical workflows
Technologies
LC-MS, Thermo instruments, AbSciex instruments, ELN
Responsibilities
Develop LC-MS characterization methods for viral vectors and nonviral particles; Profile HCP clearance and monitor impurities; Establish method detection limits and oversee method transfer; Utilize LC-MS for differential protein expression in cell lysates; Author technical documentation including IND/IMPD/BLA filings; Contribute to scientific literature and present at conferences
Seniority
Senior, hands-on IC
