Process Development Senior Scientist
Core
Develop analytical and biochemical characterization methods for pre-clinical biotherapeutic protein development, focusing on mass spectrometry and liquid chromatography to assess primary structure, chemical modifications, and post-translational modifications.
Role type
Senior IC process development scientist (analytical/biochemical characterization)
Builds
Pre-clinical candidate selection packages and regulatory submission data for biotherapeutics
Domain
Biotechnology / Biotherapeutics / Analytical Chemistry
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Mass spectrometry (MS) of proteins/peptides/glycans, Liquid chromatography (LC), Peptide mapping, Sample preparation (reduction/alkylation/enzymatic digestion), Technical documentation, Regulatory submission support, Emerging technology evaluation
Preferred skills
Thermo mass spectrometers, Agilent/Thermo HPLC systems, Data acquisition software (Chromeleon), Data processing software (BioPharma Finder, Skyline, Byonic, Byos, Expressionist), Statistical software (Excel, Origin), Biotech industry experience, Process/method transfers, Comparability studies
Technologies
Thermo mass spectrometers, Agilent HPLC, Thermo HPLC, Chromeleon, BioPharma Finder, Skyline, Byonic, Byos, Expressionist, Excel, Origin
Responsibilities
Develop analytical methods for biochemical characterization of drug candidates, Execute sample preparation and LC-MS workflows, Generate technical documents and presentations, Provide scientific results for regulatory submissions and patents, Evaluate emerging MS-based characterization technologies
Seniority
Senior, hands-on IC
