Scientist, Cell Therapy Process Development (In Vivo CAR-T)
Core
Design and execute laboratory experiments to translate next-generation in vivo CAR-T therapies from early research into robust, scalable development platforms.
Role type
Scientist, Cell Therapy Process Development (In Vivo CAR-T)
Builds
Scalable lentiviral vector production platforms and in vivo CAR-T therapy manufacturing workflows
Domain
Biopharmaceuticals, Cell Therapy, Viral Vector Production
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Viral vector process development, Bioprocess scalability, Aseptic mammalian cell culture, T-cell biology and immunology, Statistical design of experiments, Data analysis for process optimization
Preferred skills
Upstream production (suspension culture, transfection, bioreactor scale-up), Downstream purification and concentration, Viral transduction mechanisms, Primary T cell culture and expansion, Analytical characterization of drug products, Lipid nanoparticle (LNP) delivery systems, Site-specific gene-editing technologies, Flow-based cellular and PCR/sequencing assays
Technologies
Lentiviral vectors, Bioreactors, Apheresis systems, CRISPR-Cas, Base editing, Prime editing, Flow cytometry, PCR, Sequencing
Responsibilities
Design and conduct experiments to evaluate gene delivery and cell engineering strategies for CAR-T manufacturing feasibility, Lead workstreams focused on optimizing and implementing scalable lentiviral vector production, Document experimental workflows and results in electronic laboratory notebooks, Perform data analysis to enable informed decision-making by R&D teams, Participate in cross-functional project teams to coordinate experimental execution, Train and mentor junior team members
Seniority
Mid-level Scientist, hands-on IC
