Principal Scientist, Translational Science Immunology
Core
Leading translational research and preclinical development activities to support the Immunology Therapeutic Area Portfolio, focusing on mechanism of action, disease patho-mechanisms, and target validation.
Role type
Principal Scientist, Translational Science Immunology
Builds
Pre-clinical studies, biomarker strategies, and research plans for early clinical development
Domain
Biopharmaceuticals, Immunology, Autoimmune and inflammatory conditions
Required skills
Immunology research, in vitro and ex vivo study design, biomarker strategy development, pre-clinical study planning, regulatory document preparation, strategic project alignment, external scientific networking
Preferred skills
Experience translating research outcomes into early clinical development
Technologies
None explicitly listed
Responsibilities
Design and implement in vitro and ex vivo studies to investigate mechanism of action; Design PD response/biomarker strategies and assays for non-GLP/GLP toxicology and first-in-human studies; Collaborate with in vivo pharmacology researchers to provide pre-clinical studies for indication selection; Collaborate with clinical development teams to support biomarker strategy and ethics applications; Contribute to writing investigator brochures, regulatory submissions, and clinical study reports; Develop and implement Research Strategy aligned with TA priorities; Liaise between Research TA Core and Translational Research teams; Provide research input into early phase NPO due diligence; Build external scientific and industry networks for Immunology TA
Seniority
Principal, hands-on IC with strategic oversight
