LVV Upstream Senior Scientist II
Core
Develop and drive robust LVV upstream process workflows to support efficient, scalable, and reliable manufacturing of lentiviral vectors.
Role type
Senior IC upstream process scientist (viral vectors)
Builds
High-quality lentiviral vector production processes and scalable manufacturing workflows
Domain
Biotechnology / Viral Vector Manufacturing
Required skills
Upstream process development, cell culture expansion, transient transfection, stable producer-cell systems, multivariate Design of Experiments (DoE), viral harvest, process scale-up and optimization, bioreactor operation, GMP manufacturing, statistical analysis, protocol development
Preferred skills
HEK293 cell culture expertise, suspension culture bioreactor operation, JMP/MODDE/Minitab proficiency, IIT/IND/BLA project experience, technology transfer
Technologies
JMP, MODDE, Minitab, ELNs
Responsibilities
Develop and drive robust LVV upstream process workflows; Conduct hands-on experiments to evaluate innovative technologies and next-generation lentiviral vector platforms; Support technical investigations through troubleshooting and data analysis; Analyze, document, and present experimental data; Provide technical support, training, and SME knowledge to assist with the development of junior scientists; Collaborate with cross-functional stakeholders to ensure seamless transfer of developed processes to manufacturing teams; Maintain accurate, complete, and compliant records; Draft and review technical documents including SOPs, batch records, and process transfer documents.