Senior Scientist, Gene Delivery and Editing Process Development
Core
Design, execute, and optimize upstream development experiments and production processes for next-generation viral vectors (LVV and AAV) to support cell therapy clinical programs.
Role type
Senior Scientist, Process Development (Upstream)
Builds
Viral vector production platforms and clinical-grade cell therapies
Domain
Biopharmaceuticals / Gene Therapy / Upstream Process Development
Required skills
suspension culture of mammalian cells, viral vector process development, Design of Experiments (DoE), stirred tank bioreactor scale-up, cross-functional collaboration, technical writing, contract manufacturing interface
Preferred skills
upstream process intensification (fed batch, perfusion), process-analytical technology (PAT), cell line development, media/feed optimization, metabolic flux analysis, data pipelines, intellectual property generation
Technologies
shake flasks, stirred tank bioreactors, DoE software, CDMO systems
Responsibilities
Design and troubleshoot upstream development experiments for LVV and AAV production; Optimize production processes and support clinical/commercial scale-up; Lead platform development strategy and coordinate team efforts; Support research-to-development transitions and late-stage process characterization; Manage tech transfer with external collaborators (CDMOs, CROs); Author technical reports and present data to senior leaders
Seniority
Senior, hands-on IC with strategic coordination