Senior Scientist Digital Biopharmaceutics
Core
Shape and deliver digital-first biopharmaceutics strategies across drug projects using model-informed approaches to guide formulation, bridging, and regulatory decisions.
Role type
Senior Scientist Digital Biopharmaceutics (Model-Informed Drug Development) (via careerplan.io/jobs/R-261017-1-senior-scientist-digital-biopharmaceutics-at-astrazeneca)
Builds
Digital biopharmaceutics strategies, in silico predictions, and reusable digital methodologies for drug development.
Domain
Biopharmaceutics, Predictive Science, Drug-Product Development
Deliverable
production ML models | product features
Required skills
Biopharmaceutics modelling and simulation, Physiologically based biopharmaceutics modelling (PBBM), PBPK, In silico techniques, Drug product performance analysis, Dissolution science, IVIVC/IVIVR, Scripting/programming (Python, R), Cross-functional collaboration, Regulatory compliance
Preferred skills
AI/ML applications in pharmaceutical development, Peer-reviewed publications in digital biopharmaceutics, Experience across multiple dosage forms (oral solids, parenteral, long-acting injectables, inhaled)
Technologies
GastroPlus, Simcyp, PK-Sim, Electronic lab notebooks
Responsibilities
Define biopharmaceutics strategy with emphasis on digital and model-informed approaches; Apply PBBM, PBPK, and in silico techniques to predict drug behaviour and optimise dosage regimens; Build mechanistic understanding of in-vivo dissolution/absorption to guide in-vitro characterisation; Eliminate or minimise in-vivo studies through robust model-based justifications; Engage with cross-functional teams and external partners to champion digital strategy; Author internal and regulatory documents ensuring compliance with global guidelines.
Seniority
Senior, hands-on IC with strategic project leadership
