Senior Process Engineer, Viral Vector, Upstream
Core
Design, execute, and optimize upstream Lentiviral Vector (LVV) processes for suspension cell culture at clinical and commercial scales to support AstraZeneca's Cell Therapy portfolio.
Role type
Senior IC process engineer (viral vector upstream)
Builds
Suspension-based LVV production processes for clinical and commercial supply
Domain
Biopharmaceuticals / Cell Therapy / Viral Vectors
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
suspension cell culture, transfection/infection strategies, media/feed optimization, single-use rocking-platform bioreactors, stirred-tank bioreactors, upstream-harvest interfaces, statistical DOE, data analytics, cGMP documentation, scale-down modeling
Preferred skills
scaling suspension LVV processes to pilot/clinical scales, linking upstream parameters to analytical outcomes, regulatory filing contributions, Lean/continuous improvement implementation
Technologies
single-use systems, process automation/PAT, ELN/LIMS
Responsibilities
Plan and perform experiments to optimize LVV upstream processes for titer, quality, and robustness; execute unit operations across seed, production, and harvest interfaces; develop DOE studies and identify CPPs/CMAs; prepare technical transfer packages for GMP sites and CDMOs; apply Lean practices to track KPIs and drive operational excellence.
Seniority
Senior, hands-on IC
