Sr Scientist – Product Discovery – Temporary Position
Core
Design, plan, and execute in vitro and in vivo pharmacology characterization of novel lentiviral vector candidates and reprogrammed CAR-T cells to support IND-enabling decisions for cell and gene therapies.
Role type
Senior Scientist (Product Discovery, Nonclinical Development)
Builds
Lentiviral vector candidates and CAR-T cell therapies for oncology and immune-mediated diseases
Domain
Biopharmaceuticals, Cell and Gene Therapy, Immunology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Lentiviral vector characterization, CAR-T/TCR-T in vitro assays, in vivo pharmacology studies in humanized mouse models, flow cytometry, ddPCR/qPCR, ELISA/MSD, Western blot, nonclinical regulatory reporting
Preferred skills
Spectral flow cytometry, high-content imaging, single-cell approaches, CRO oversight, integration site analysis
Technologies
Lentiviral vectors, CAR-T cells, humanized mouse models, electronic lab notebook
Responsibilities
Design and execute in vitro assays for transduction efficiency and cytotoxicity; Direct in vivo studies in humanized mouse models; Generate integrated data packages linking vector attributes to outcomes; Author nonclinical study reports and regulatory sections; Present findings to internal governance and external partners; Maintain rigorous GLP-aligned documentation
Seniority
Senior, hands-on IC
