Scientist Antibody Discovery
Core
Design and execute antibody discovery workflows using display methods (phage, yeast, mammalian) and NGS to mine antibody pools, while optimizing high-throughput mammalian cell-based production platforms for recombinant antibodies.
Role type
Senior IC antibody discovery scientist
Builds
Lead antibody candidates and optimized production workflows for therapeutic programs
Domain
Biopharmaceuticals / Antibody Engineering
Deliverable
production ML models | product features
Required skills
Antibody discovery, protein engineering, expression and validation of biologics, display methods (phage, yeast, mammalian), library generation, NGS, mammalian cell culture (CHO, HEK293), chromatography (AKTA), HPLC-SEC, ELISA, CE-SDS, SEC-MALS, DSF
Preferred skills
ML-based approaches for display methods, cryo-EM for epitope analysis, high-throughput automated protein purification, antibody bioinformatics, mAb characterization (FACS, BLI, epitope binning)
Technologies
AKTA, HPLC-SEC, Kingfisher, ELN
Responsibilities
Design discovery workflows and deliver lead candidates, apply in-vitro display methods for sequence discovery, perform DNA preparations for transfection, establish scalable transient and stable expression workflows, purify proteins using chromatography, analyze purified proteins via HPLC-SEC, assess early-stage candidates using molecular methods, maintain ELN data
Seniority
Senior, hands-on IC
