Senior Research Associate / Associate Scientist, Nonclinical
Core
Design, develop, and optimize cell-based and biochemical assays to measure tRNA activity and efficacy for early-stage discovery and IND-enabling studies.
Role type
Senior Research Associate / Associate Scientist (Nonclinical)
Builds
Cell-based assays, in vitro/in vivo sample processing, and biomarker data supporting tRNA therapeutic programs
Domain
Biotechnology / RNA therapeutics / Nonclinical research
Required skills
mammalian cell culture, cell line characterization and development, DNA/RNA delivery methods, molecular and cellular assays, assay design and optimization, data analysis
Preferred skills
RNA therapeutics experience, primary human hepatocyte culture, high-content imaging, CRISPR genome editing, disease-specific cellular assays
Technologies
PCR/qPCR, Western blot/Jess, immunostaining, luciferase/bioluminescence assays, flow cytometry, ELN, IncuCyte, confocal microscopy, MSD, Luminex
Responsibilities
Design, optimize, qualify, validate, and implement cell-based assays; Execute in vitro assays and process samples; Conduct biochemical assays for biomarkers; Perform mammalian cell culture and cell line development; Analyze and present experimental results; Contribute to SOP development; Manage multiple studies in parallel
Seniority
Senior, hands-on IC