Principal Scientist, Structural Biology / Protein Biophysics
Core
Lead the build of an amyloid research platform by producing assay-grade proteins, developing aggregation assays, and characterizing aggregates to advance therapies for amyloidogenic diseases.
Role type
Principal Scientist, Structural Biology / Protein Biophysics
Builds
Assay-grade recombinant amyloid proteins, rigorous aggregation and structural assays, and cellular models for toxicity/seeding/clearance.
Domain
Biotechnology / Amyloidogenic diseases / Protein Biophysics
Required skills
recombinant protein expression and purification, kinetic assay design and analysis, mass spectrometry, NMR, amyloid aggregation mechanisms, CRO management
Preferred skills
LiP-MS, HDX-MS, cryo-EM, atomic force microscopy, statistical design of experiments, laboratory automation
Technologies
Mass spectrometry, NMR, AFM, cryo-EM
Responsibilities
Establish in-house production and QC of assay-grade recombinant amyloid proteins; Design and analyze amyloid aggregation experiments; Characterize amyloid aggregates via mass spectrometry, NMR, or AFM; Support build of cell-based assays for evaluating amyloid toxicity, seeding, and clearance; Evaluate inhibitors of amyloid aggregation and translate findings into cellular models; Scope, contract, and manage CROs and academic collaborations.
Seniority
Principal, hands-on IC with technical direction