Director/Senior Director, Computational Chemistry
Core
Lead the design and optimization of heterobifunctional small molecules (e.g., PROTACs) and drive computational strategy for molecular ideation and prioritization.
Role type
Senior IC computational chemistry leader (Director/Senior Director)
Builds
Heterobifunctional small molecule therapeutics
Domain
Biotechnology / Computational Medicinal Chemistry
Deliverable
production ML models
Required skills
Computational medicinal chemistry, structure-based drug design, cheminformatics, ADME optimization, molecular modeling (docking, FEP), team leadership
Preferred skills
Heterobifunctional small molecule experience, ADME optimization for large flexible molecules, early-stage biotech experience
Technologies
Docking, FEP, Cheminformatics tools
Responsibilities
Define strategic vision for heterobifunctional small molecule design; lead cheminformatics strategy and workflow development; direct ADME and developability assessments; champion structure-based and AI/ML-assisted modeling; serve as strategic scientific partner across cross-functional teams
Seniority
Senior, hands-on IC with people management
