Principal Associate Scientist, Biology
Core
Design and execute cellular and molecular experiments to characterize Helicon peptide candidates, understand their mechanism of action on intracellular targets, and generate decision-enabling data for pre-clinical oncology programs.
Role type
Principal Associate Scientist (Biology, Pre-clinical Oncology)
Builds
Cellular and molecular assays, disease-relevant models (2D/3D), and pharmacodynamic/biomarker hypotheses for Helicon candidates
Domain
Biopharmaceuticals / Oncology / Peptide therapeutics
Required skills
Mammalian cell biology, cell culture, quantitative cell-based pharmacology, assay development, HTRF, AlphaLISA, CETSA, Western blot, Co-IP, qPCR, Flow Cytometry, ELISA/MSD, CRISPR/Cas9, RNAi, viral expression/transduction
Preferred skills
Oncology drug discovery, peptides, targeted protein degradation, pharmacodynamic biomarker development
Technologies
HTRF, AlphaLISA, CETSA, NanoBRET, qPCR, ELISA/MSD, Flow Cytometry, CRISPR/Cas9, RNAi
Responsibilities
Design, optimize, and execute cell-based assays for target engagement, potency, and mechanism of action; Develop and qualify new assay systems and disease-relevant models (cancer cell lines, primary cells, organoids); Investigate biological contexts of drug sensitivity and resistance; Collaborate with Translational Biology and Pharmacology to translate findings into PK/PD studies; Generate decision-enabling data for lead optimization and IND-enabling activities; Maintain rigorous experimental records and data integrity.
Seniority
Senior, hands-on IC