Director/Senior Director, Computational Chemistry
Core
Lead the design and optimization of heterobifunctional small molecules (e.g., PROTACs) to create new therapeutic modalities.
Role type
Director/Senior Director, Computational Chemistry
Builds
Heterobifunctional small molecules and computational tools for molecular design
Domain
Biotechnology / Computational Medicinal Chemistry
Deliverable
production ML models | product features
Required skills
Computational medicinal chemistry, structure-based drug design, cheminformatics, ADME optimization, molecular design strategy, team leadership
Preferred skills
Heterobifunctional small molecule experience (PROTACs), ADME optimization for large flexible molecules, early-stage biotech environment
Technologies
Docking, conformational analysis, FEP, cheminformatics tools
Responsibilities
Define strategic vision for heterobifunctional small molecule design; lead cheminformatics strategy and workflow development; direct ADME and developability assessments; champion structure-based and AI/ML-assisted modeling; serve as strategic scientific partner across cross-functional teams
Seniority
Senior, hands-on IC with leadership
