Scientist | RNA Biology & Neuromuscular Gene Therapy
Core
Design, execute, and interpret experiments to optimize AAV-tRNA platforms for neuromuscular disease applications, including studies in animal and in vitro models.
Role type
Research Scientist (RNA Biology & Gene Therapy)
Builds
AAV-tRNA therapeutic constructs and data for neuromuscular disease treatments
Domain
Biotechnology / Gene Therapy / Neuromuscular Pathology
Required skills
RNA biology, gene therapy, AAV vector design, in vivo administration, rodent model handling, molecular analysis (qPCR, RNA FISH, Northern blotting, histopathology), toxicology assessment
Preferred skills
Experience with neuromuscular disease models, AAV capsid evaluation, suppressor tRNA development
Technologies
AAV vectors, qPCR, RNA FISH, Northern blotting, histopathology
Responsibilities
Develop and test novel AAV-tRNA constructs; Evaluate AAV capsids and administration routes; Execute in vivo and in vitro efficacy studies; Design and execute toxicology animal studies; Contribute to next-generation RNA therapeutics; Interpret complex datasets and communicate findings; Collaborate with vector manufacturing and regulatory teams
Seniority
Mid-Senior, hands-on IC