Vice President, Portfolio Chemistry
Core
Lead Revolution Medicines' multidisciplinary Portfolio Chemistry organization, providing strategic and scientific leadership for advancing oncology programs from validated hit series through development candidate nomination.
Role type
Executive-level VP of Portfolio Chemistry (Medicinal Chemistry)
Builds
Oral RAS(ON) inhibitors and small-molecule therapeutics for RAS-addicted cancers
Domain
Oncology / Medicinal Chemistry / Drug Discovery
Required skills
Medicinal chemistry, structure-based drug design, optimization strategies, candidate selection, computational chemistry, AI/ML integration, CRO management, organizational leadership, budget management
Preferred skills
Oncology drug discovery, IND filing experience, scientific publications/patents, alternative modality drug discovery (molecular glue, ADC)
Technologies
AI/ML tools, computational chemistry platforms, digital drug discovery tools
Responsibilities
Define and execute long-term strategy for expanding the portfolio of novel small-molecule therapeutics; Develop and execute chemistry strategy supporting advancement from hit validation through development candidate nomination; Partner with Early Discovery Chemistry to establish criteria for transitions from hit identification into portfolio medicinal chemistry; Drive integration of chemistry with computational chemistry, AI/ML, and data science; Lead organizational planning, resource allocation, talent strategy, and capability development; Prioritize resources to maximize portfolio value; Translate portfolio strategy into differentiated chemistry programs; Champion predictive analytics and computational approaches to accelerate DMTA cycles; Manage a high-performing group, sustain productivity through strategic hiring and mentoring; Position the MedChem function as a bridge across Research functions.
Seniority
Executive (VP), strategic leadership & organizational management