Senior Research Investigator / Research Leader (Translational Pharmacology), London
Core
Shape and advance an exploratory research portfolio in neurodegenerative diseases, translating deep mechanistic insights into robust therapeutic hypotheses and decision-critical experimental workflows.
Role type
Senior Research Investigator / Research Leader (Translational Pharmacology)
Builds
Therapeutic hypotheses, target validation packages, and decision-critical experimental workflows for novel medicines.
Domain
Neurodegenerative diseases, Translational Pharmacology, AI-driven drug discovery
Deliverable
production ML models
Required skills
Deep mechanistic understanding of neurodegenerative disease biology, Expert practical knowledge of translational models (in vitro, ex vivo, in vivo), Design of robust screening cascades, Managing outsourced studies with CROs, Collaborating with bioinformatics and computational biology teams
Preferred skills
Strategic compound de-risking and SAR, Biophysical and biochemical screening techniques, Early clinical biomarker discovery
Technologies
SPR, TR-FRET, mass spectrometry, high-content imaging
Responsibilities
Define and evolve neurodegeneration research strategy, Integrate insights across human genetics and clinical datasets, Develop human disease-relevant therapeutic hypotheses, Profile novel chemical matter from in silico pipelines, Design assays to benchmark AI-designed molecules, Manage timelines and delivery of decision-quality data
Seniority
Senior, hands-on IC with strategic leadership